Ban depan pakai Pirelli Diablo Rosso Corsa II 120/70-R17, sedangkan belakang Pirelli Diablo Rosso Corsa II 180/60-R17. Untuk suspensi, Panigale V4 R memakai Showa upside-down fork berukuran 43 mm, dan single-side aluminium swingarm with Sachs shock absorber.